I can't speak to raising vieleds, but in general terms , I'm sure my Panther experience is similar.
What is difficult for a long time keeper , would probably be different than that of a newbie.
I expect that newbies will have trouble " reading" their chameleon. With experience, you begin to notice the subtle changes to your cham that indicate issues , such as edema, gout, dehydration, overfeeding , underfeeding, lethargy, parasites..etc. Newbies tend to either under react and find that one day they have a crisis on their hands, or tend to over react and then become paranoid to every perceived change.
My suggestion is to research as much as possible. Read and search this forum on health issues. Ask questions on this forum. You won't be ridiculed for asking a "stupid" question, because everybody here has asked the same questions in the past. Find a mentor either in your community or online. Sometimes a close friend in the hobby can be a great help and moral supporter.
Personally, after several years at this, my own difficulty is balancing supplements. I think of it as a pendulum swinging back ( too much supplementation) and forth ( not enough). I will never get it perfectly correct, so I am resigned to constantly tweaking supplements, by reading my chams needs.
Good luck