Dude, cyber has been doing this for longer than most people currently posting on these forums.
Well to be fair, I have never bred Chams. Yet.
I have bred other reptiles, and I do get around and talk to alot of people, and have made alot of planning, and spreadsheeted it a few times. Me and the wife have thought about it a few times. We might actually start, however we never did it before because it needs server dedication. There is no going back, once there is eggs, that's it, you now have eggs to care for. That was never a guarantee, that we felt comfortable taking on, with something as demanding as a Cham, with already having kiddos and everything.
Jack's is right, there is a hefty upfront cost. However after you make that back, there is definitely profit to be made. How you value the profit to hours spent, and what hours classify as work and which as hobby, is all up in the air, and going to be derivative on a per person basis. However to say there is no profit, I can't say I agree with.
Plus like Night said, and I think I touched on and Bill did in the podcast. You can breed Veilied and stay afloat. You might make enough for a pizza, but not much more. That's more of a passion project. Now increase animals price by 275, per. That's all profit. Once again, this isn't taking hours spent into account. It's very situational.
For us, it was always a thought, as we have a business that is semi home based already, I am already home all day, doing pretty much nothing (my slow business lol) so putting that time to better use, would be huge profit for me. As I can't go do a job that pays more. In that situation, my time isn't as valuable, as I am making money sitting here anyway

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You will never be Trump. But you can defiantly make a decent living breeding Panthers. Especially if you live in Florida.