They're all different so it's hard to know. She won't likely like you while you're doing it to her depending on how you do it.
Just be sure you don't squirt it but rather ease it in and make sure it doesn't get into her lungs by putting it far enough back in the mouth.
Some people inject the mess into an insect and make sure the chameleon eats the insect.
This might help...the towel makes it so they can't get a grip on you and struggle..