While I disagree with Chris about the principles of cross breding panther locales, I would say it's not a right/wrong thing in this case. It would be downright stupid. They are a very rare form in captivity, and should be established more before you go on and do something like that.
Fact is, most crosses are ugly. All of them, in fact, when first crosses, are not as nice as the natural locales. Selective forces have shaped their coloration for a very long time.
Crossing them WILL result in interesting and beautiful color variations, in time, but that's the key.
It will take lots of time, lots of crosses, lots of selection and lots of ugly babies before you get something that looks as nice as one of the natual locales.
If you were to be sure they didn't get mixed up with natural locales, then go at it. But it is going to be a long long time, and a lot of money, before ou come up with a line of babies that is worth propagating.
The Kammers have some that are up there, but look at how much they have been crossed - the nice ones have 3-4 locales mixed in. That shows how much time and how many corsses were needed to result in an animal like that.
If selective breeding can turn leopard geckos into what they are now, it could make many more panther varieties than exist in nature. That's one of the motivating factors behind such crosses. Another one is one-time breeders, who do it for the heck of it, and then have a bunch of ugly little babies to sell. And the REAL problem, which woudl piss me off, is when they see their 30, ugly little babies crawling around, and can't sell them for more than $20... and look at the price of pure females... and then you have yourself a chain reaction of genetic frustration that may never end.
One person making a "little lie" (they are, after all, HALF ambilobe...) could mess up the bloodline of thousands of chameleons in a few years time.
You hatch out a mixed clutch, and you will be greatly tempted to sell the females as pure. Who the hell wants a mixed female? Not many people.