Brody, I am sure that essential oils cannot harm any skin. Oil is different from water, and Repti Shedding Aid specifically lists chameleons as one of the species for which it is indicated. When I had snakes they also got essential oil & vitamin E products prescribed by the vet as a shedding aid. However, my pythons also enjoyed bathing in water buckets which the chameleons don't seem to be keen on. However, Yoshi enjoys standing in front of my water spray bottle when I use it, whereas my girl, Lizzie, does not like it and moves away. So, chameleons seem to have different preferences when it comes to having light showers!