My train of thought on this is If you need to maintain a higher level of humidification like with montane species then I use a substreight, but when humidity isn't as hard to maintain as in veiled, or panther I find no substreight to be best, and easer because like was said it has to be set up properly, and maintained. How often you mist depends entirely on your cham's drinking habits, and your humidity requirements. It is something you will have to work with and figure out yourself I'm afraid. Just remember some cham's take a while before they realize hay I think I will drink. Good luck I hope I was of some help.