When younger, chameleons will shed far more often, usually every 3 weeks or so. As adults, you might see it once every two months or so, just depends on your guy's growth. Misting will definitely help ease the process and move it along. You'll see them rubbing up against sticks, stretching, yawning etc. All normal. NEVER try and pull any of the old skin off. You could end up damaging the new skin coming in underneath.