Any kind of squeaky noise that is caused by their breathing should be investigated. There may be an upper respiratory infection (URI). Please provide us with more info on your chameleon and setup: [THREAD=66]some suggestions[/THREAD]. Until then, make sure your temperatures are correct. One of the contributing causes of URI are low temps. Some other symptoms would be labored breathing, an expanded chest, gaping, string or bubble mucus in the mouth, ...