Like Solid said, those are the differences but I've never thought that made them harder. It's a question of making small changes to your cage to accommodate them and that's about it, the day to day care is about the same except with less supplementing with minerals/vitamins.
They were the first species I owned and all I did differently was:
- Use a lower watt bulb to keep the highest temp at 80-83*F
- I run the AC so my house was at 75*F anyway
- Got a misting system and lots of live plants to keep the humidity high. If it didn't work I just taped a sheet of plastic to the back 3 walls of the cage and that did the trick.
- Provided lots of water because mine loved to drink
- Provided calcium mainly through high-calcium insects and supplemented very rarely.
And that was it. The differences seemed to me pretty easy to take care of. And he was such a sweet chameleon, he was a great chameleon to start off with.