Depends on the cham.
Certainly a spray to the face is not what anyone likes. My cham likes it when I mist/spray him with slightly warmed water from behind. He runs from cold water mists. (As would I)
Some chams just like getting misted on their own terms instead of randomly shot when the keeper is ready. When my misting system goes on, it takes a minute or two, but he slowly eases into that area to get wet.