Sometimes the girls like to play coy and get the males to chase them. Don't take her out right away unless she is biting him...but stick close. Get some gloves on just in case you have to go in there while she is trying to bite.
I have the same problem for a long time............what i did was......introduce the male panther into the female's cage. First for about 5-10 min... then longer....for about a few weeks.......Waala.....they mated yesterday!!!
Sometimes...when the female is not in heat...she will be hissing and biting too!! Or sometimes she is palying hard to get!!
well i tried what ChameleonsTree had told me before i went to school. and it worked... my female seemed like she hated him the first 10 times i tied but when i put him in this time she flared at him a little bit but it workd! my male had a hard time figuring out his stuff for a couple minutes but he got the hang of it