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There are many possible causes to edema. Many of us have invested a lot of time and money in to edema and its possible causes. You cant treat it if you dont know what is causing it. It could be true edema, which may be form some type of imbalance, infection or organ failure, it could be something other than edema such as fluid draining from an infection. Its just not easy and many of us still haven't solved it.
It's the first place to start to do some diagnostics like fluid analysis of the edema and bloodwork to look for organ dysfunction, although reptiles don't have the characteristic changes that mammals do on their bloodwork. There is almost no established data on gular edema in reptiles, and it seems to be over represented in chameleons versus other species. It is not specifically known why this build-up occurs but it is speculated to possibly be a symptom of mineral imbalance (possibly calcium) or an indication of liver or kidney disease. The best treatment in the experience of some is as much natural sunlight as possible, significantly increased hydration and ensuring adequate calcium supplementation with very limited phosphorus content in food to promote good kidney health. Sometimes the edema goes away with time, and sometimes it is permanent, but may fluctuate. Occasionally edema is seen with gravid females and it resolves once the eggs are laid. I've had several chameleons get gular edema - two I suspect was due to accidental excess vitamin A which went away over time with the suggestions mentioned above. Another was due to overwhelming kidney failure shortly before he died. I had a different senior chameleon die of kidney failure that never showed edema. We still don't know very much about it despite our best efforts.
I would expect him to not eat if an internal problem was occurring.
If only things were that straightforward. It would make my job easier!