They can't really hear at all, but they can feel vibrations. Do you mean you are playing music on your phone, or actually playing an instrument? Either way chameleons like quiet low traffic areas, but if it's just some music on your phone, it probably wont bother him very much. But if it were up to me I would play my music somewhere else, because I sometimes dance with the music,(haha!) and my chameleon doesn't like the vibrations very much.