Hairfarm, I don't think anyone is doubting that crosses of the first couple generations will be flawless is appearance and behavior wise, but there has been some findings that further generations down the mixed lines are creating instable fertility in both sexes.
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All I have ever seen regarding this topic has been anecdotal. Can you point me at anything scientific or published or anything? I don't understand how a population would have to continually breed into itself in order not to risk sterility. Limiting available mating partners either in the wild or in captivity greatly increases the probability of inbreeding. The natural variations within each population would tend to support the hypothesis that the opposite is occuring anyway, wouldn't they?
Panther chameleons have a very high reproductive rate. Why? Because most of those that hatch in the wild never make it to breeding. What you have to remember is that the clutches of pardalis that hatch in captivity have a very high, very unnatural survival rate. Many of these animals not only wouldn't survive to adulthood in the wild, but wouldn't pass along their genes either. We don't know which would have been the most fit to survive in the wild (and reproduce) but we artificially create "pairs" of them based on our own tastes or, in a lot of cases, budgets. Multiple generations of artificially selected breedings will risk having inherited problems regardless of whether they are the same locale or not. All animals in the wild have social structures that actively discourage inbreeding and "linebreeding" which many breeders practice. I know if I only saw a couple potential mates in my lifetime, like most captive born chameleons experience, I wouldn't care what they looked like and neither do they.
Look at pure breed dogs vs mutts. Boxers get cancer, sheperds get hip dysplasia, some breeds of terriers have skin and alergy problems, some breeds are really dumb, etc while mixed breed dogs do not suffer from these problems to the same degree.
Panther chameleons need to increase the risk of inbreeding by staying within their natal populations so that they don't go extinct? Sorry, I just can't accept that until I see research evidence....and probably a good proposal that explains why the contradiction works so successfully for them too.