Well, if it is a scale insect, I presume you would have to pluck it off. But when I did that on my plants, I found that those insects really do clamp onto the leaf strongly.
So you'd probably have to remove it very carefully with tweezers to prevent it from damaging your chameleon's skin when it comes off.
I really have never experienced that, so maybe it is best to wait for someone else's advice on it, or maybe just let a vet have a look at it.
If it isn't an insect, and is part of the cham's skin, then plucking it off would certainly harm the cham.
I just re-read what you posted after I posted: I presume you mean by "It looks like more a scale" that it looks like a scale on the chameleon's skin, and not a scale insect. If that's the case, then at best it could be nothing to worry about, just some random colouration, or at worst it would be something your vet would have to treat. The fact that you say that this cham is not as healthy as the others in its group makes me think that you should probably have it checked out by a vet regardless of whether the red spots are a problem or not.