For screen cages Yes, With glass its completely different and it will hold humidity way longer (Meaning water sits around a lot longer). Since you only use very little wattage in a glass you will have standing water for a lot longer. For a small exo terra for a panther i was running around 2mins split up between the day and that was good when he was on 10hour cycle for dry winter in Canada. Now he's grow up and in a dragon strand breeder cage which has 3 solid sides and he gets 6mins a day of misting a day spraying split by 2mins a spray every 4 hours. Breeder cage has double nozzle added so it uses a little more water than normal.
Husbandry is different between glass and screen. Don't have to be living in a desert either to use one,
Christopher V. Anderson who wrote one of the best articles on it i'm pretty sure was living in Florida when he wrote it. Its a little out dated because bigger vivs did not exist when he wrote it but its a great read, he was also on the
chameleon breeder podcast talking about glass.
I'd be worried of bare bottom though i always made a drainage layer like you would in a bioactive terrarium and add live plants.

The fans not needed and will just dry it out quicker the circulation is perfectly fine in exo terras they create a chimney effect no fans need to be added imo. If you do choose to keep it more spraying will be required.
Also make sure basking lights are on for atleast 30mins before first spraying so the chameleon can warm up first.