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If the area is puffy and there is blood at all you will need to take him to a vet to be sure that an infection has not started. It's very VERY easy for them to aqvuire an infection.
Some people have had nails grow back some haven't I really am not sure why that is. My friend adopted a Cham that has 3 missing and over a 6-7 month period he's had him they have not grown at all. I'm going to take an educated guess and say if the Cham is young - since their nails are still growing so its not exactly "growing back" but just still growing. It seems as though once its a mature adult that they have the only nails they will get and will not "grow back"
But I could be wrong. Ill just have to wait for someone else to chime in, these are just my thoughts on the subject from having researched chameleon illnesses and injuries for the past years.