For many people it is worth it. me included.
However For many people, it turns out NOT to be worth it. You have to have a considerable interest in chameleons AND in insects, imho, or why bother?
chameleons dont give back the way a dog, bird, cat, rodent pet or even a beardie does. They often dont want anything to do with their keepers whatsoever. They are fairly costly, in terms of upkeeping proper lighting, vet bills and such. There is a daily time commitment, cleaning up poop, watering, raising bugs, etc. And its not easy to find a cham-petsitter so planning even short vacations can be logistical chores.
I've seen heard and read about far too many people who get a chameleon only to realize 6 months later that its not what they had fantasized it would be like. the "cool" factor wears off. The cage cleaning becomes a chore. The crickets are noisy. etc Fecals dont get done, basic or severe health issues come up and are not properly addressed, expensive vet bills are the excuse for not doing anything, and the chameleon ends up suffering.
Basically, if you cant set aside an hour a day, if you think the cost of the chameleon itself is expensive, or if you havent got a thousand in the bank at all times for emergencies, dont do it.
If you CAN do all of the above AND you think you can sit and watch a slow moving, fasinating creature from afar and that's enough for you - Go for it. I love having chameleons, and its been well over ten years now. Im addicted!