Your understanding of selection is a bit off. IF you took just a pair of chameleons, and had them start a founder population, in the wild, anywhere, they would be subject to natural selection. Inbreeding is a necessityin small populations.
That's the beauty of natural selection - it filters out deleterious genes, less-suitable phenotypes, or even behaviors that are incompatible to the long term health of the population.
Inbreeding is, over time, esentially a non-issue when you have selective factors eliminating the sickly and ill animals. Any of the "bad" genes isolated by breeding with a small gene pool will be nixed by selective forces.
So, even though the population was founded by a small genetic pool, it is proably quite healthy.
Now, if those animals were not subject to selective forces, like in captivity... well, then you have issues.
the chameleons wild in the US are, in effect, evolving to live in their new territories. In time, you'll see a difference in behavior, appearance, and requirements for them. Natural selection happens even if they're not in their natural range.