The word stress is overused. When we say it, we usually mean it as a bad thing, but chameleons, humans, and all animals live under stress constantly. Stress could be (as bill strand mentions) having a cold draft on you, but it could also be exercising. One being healthy and one causing illness. Stress=stimulation, good or bad. So him running up your arm is stress in a way, but it's not bad if he's choosing to do it and he can get a chance to relax. One thing about this behavior, it often means they are unsatisfied with their cage in some way. Whether it is lacking perches, too low to the ground, uncomfortable temp/humidity, etc. Some will do this in a perfect setting too though, so no worries. IME especially during summer, maybe to look for a mate. My Panthers do this and I hate handling them lol. Put them where they want to get(usually in the sun) and any interest they have for you disappears. Chams, like cats, treat us as an instrument to get what they want lol.