Having small enclosures is getting more and more published by some authors, and even though i do not necessary agree with this principle, i have to admit that it is possible to maintain them in a good and healthy way, so i think it is viable.
However, i prefer the good old "bigger is better" expression. As i can see from my chameleon (a Furcifer Pardalis), he likes to wander for meters and meters everyday (or perhaps i should say feet here!), to the point that i even had to put some ropes on a wall to let him go explore wherever he wants to (along with close supervision of course!).
On a side note, one question that has been asked in this topic was particulary good: "how can you know that a smaller side is good for your chameleon?". These criterias are, in my opinion, the center of this discussion. It could be health, signs of stress, age, death causes, mood, or whatever... But any of those i have named couldn't justify a scientific and valid opinion, at least, as far as i know, because they can all be provoked for other reasons...