I have a similar situation going on I’ve noticed the past two month my chameleon has been losing weight an has bumps on both back legs but they didn’t start to pop up until like two months ago he did start to gain some weight an got filled out not over weight or anything to scary just grew bigger an Thai morning he was very weak I couldn’t tell if he was dyhrdated so I hand gave him water from a string an I put him on a branch in the shower so he could get all that steam his back legs seem weak at the hips which those are the ones that are fatter an he has lost a lot of weight I noticed he is eating but only a few at a time not big amounts like normal he just seem very weak when he tries to stand I’m gonna take him to the vet tomorrow morning I hoping whatever it is that it’a reversible an he doesn’t die on me it would break my heart his jaw an everything else look okay so I don’t think mbd ..For those still interested about mr littles diagnosis, he went back to c.s.u. today as planned. He hasn't shown much signs of improved strength, but did blood work again and uric acid levels were normal which rules out gout. Everything was normal, calcium and phosphorus were good. No signs of renal failure, no signs of mbd. Fecal sample was normal, no paracites.They didn't find anything other then a possible case of periodontal disease. No mouth rot, that was visible. C.s.u does not have a diagnosis at this point still. He will be on antibiotics once every 9 days for the next month or 2 that is administered by a needle. They do not believe it is due to old age given all vital organs are functioning properly. Arrgghhhh these little guys are tricky. Please keep mr little in your prayers, he is doing alright right now, we can just only hope at this point the antibiotics do thier job.