Thanks for the replies. Luckily, no other reptiles in the house we have to worry about it spreading to. Also, cleanliness is not an issue in our household. I gave him the best environment and habitat possible. I purchased Archie Jan 5th of this year. I did not know to ask the question if he was wild caught, but I am going to make the assumption he was as I have read most Gracefuls are. My best guess is he had it when I took him home. I wish I was more educated on chameleons before I purchased him and I might have a healthy chameleon now. In any case, I am the one that decided to give him a home and care for him and am trying to do the best for him now as he is in my care. We are going back for a followup visit Monday and also get additional antibiotics so I can at least try to help him. Of course I don't want him to die in pain either and will look to my vet for signs that we need to look at other alternatives.