What is this bump on my chameleon?

It may be a papilloma, which is basically a warty growth. A vet can remove and biopsy it, which will tell you what it is. If it is a papilloma, it doesn’t have any dire effects on your cham. However, it can be transmitted to other chams/reptiles so good hygiene practices are important…wash hands between handling, don’t use the same tongs, dishes, etc.
 
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