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Each person will find his own unique misting schedule. The guide lines are this.
*Most Important* - that your cage bottom as well as plants/plastic leaves dry out between mistings. This is hugely dependent on if you have some sort of drainage system. Wether it's custom built, drainage pan, drip easy, or just plan pvc bottom with no drainage.
Your household humidity and how much you use heat and air conditioning will play a large role as well.
Do not focus so much on maintaining humidity. We found in our 8x10 adult breeder room (18 cages) that misting 3 times a day for 2.5 minutes each achieved our goals. We use drainage pans supplied by dragonstrand. We drill holes into the pvc bottom to allow proper drainage. This allows the chameleons to not only bathe for hygiene reasons but also to get some good water. Most importantly we get dry out times pretty quickly and are able to provide them with plenty of water. Too much can cause upper respiratory infections among other things.
So back to the point. Mist one hour after lights turn on and 3 to 4 hours before lights go off. Try 2 minute durations twice a day
And if your achieving proper cage dry out (cage is actually dry atleast an hour or two between mistings) try adding a 3rd misting.