I find reading posts/threads like this upsetting. There must be a post like this at least once a week or more often. I write a long explanation of what I think is happening based on years of studying under some of the best animal trainers in the world and based on what I know about the natural history of chameleons. (Natural history is the study of animals in their natural environments usually by observation, not experimentation.)
My explanation usually goes something along the lines of chameleons aren't social, they don't interact socially with their own species except to mate. I explain that since they don't have chameleon relationships, they will not form one with you other than to learn that certain things happen. I explain that a chameleon views humans as predators and always will although they will often over time learn that the you don't pose an imminent danger to their lives, but others remain in mortal terror of humans their whole lives. I explain that calming down upon being removed forcibly from their cage is often a response to a stress overload and has nothing to do with enjoyment. And then I will explain how stress will suppress the immune system and ultimately cause illness. I will be met with disbelief by people--often people with their first chameleon that is still a baby--who will tell me how much their chameleon likes being handled, etc., etc., etc. Then months later I will read posts by these same people in the health section asking for help because surprise surprise, they have health issues. Or a not-so-novice keeper will write a post of yet another of their beloved chameleons dying or gravely ill at a young age
Since time immemorial chameleons have evolved to be invisible, to not be seen. They do not flee; they do not fight. They hide. They don't want to be seen and they don't want to be handled. They are not a Poodle.
It is very disheartening to see the same mistakes repeated over and over again. I think maybe I need to take a sabbatical and just let you novices and not so novices get on with killing your chameleons. Obviously I am wasting my time trying to help.