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Yes, his eye looks droopy. Do you have a reptile vet that's experienced with chameleons? In the mean time fill out this form and give as much detail as possible. https://www.chameleonforums.com/how-ask-help-66/
This is not my Cham, I seen it in Instagram. The one eye is droopy looking and the other eye seems to not open at all, what are your thoughts ?
We'll never know. Nothing can be diagnosed or even adequately guessed at on the basis of one little photo.
Go back and read jannb's post - yes that would be something worth seeing a vet.