Do you have any Silver Sulfadiazine creme?. You could try that. My chameleon had something that looked identical. I had the spot tested and it came back fungual. The vet suggested trying that. I put that on the spot for about two weeks. It is gone but it made a little scar on the scale and it is black now. There is a virus called Pox or Papilloma which caues hornlike spiky growths. That does not appear to be the case here, but if your chameleon has it, they will probably start popping up in different parts of his body. You seem to be doing the norm in care of your chameleon. I would say if he is missing his prey, that would be an eye issue. Reptivite contains Vitamin A, so he is getting some from your multivitamin. Other than lack of vitamin A, I would not know what else would cause bad eye sight unless he has some type of injury or some other disease.. Do both his eyes look normal??