I handle mine everyday and he does not mind it at all, but that is the key. If they are running and hiding and you are digging them out of the cage then that is a no no. I got my panther at about 4 1/2 mos and (with the instructions from the breeder) gave the chameleon 2 weeks to settle in . Then I started using a small stick for him to perch on. Took him out every day or so sitting on the stick for like 5 minutes. Then gradually worked up more time and started using my hand. The thing that really made my cham not afraid of me was opening my cage door and he comes out on the top of the door and then I put my hand out to him and he usually climbs on. If not, I dont force him, and I just let him stay there. I noticed my chameleon is way friendlier out of the cage than in. When I free range him he does not mind being handled or moved in the least bit. Sometimes I have the door open and he is sitting on a branch and I sitck my hand out and he jumps right on. The thing I discourage is when they are completely stressed out, puffed up and hissing(which actually mine has never been come to think of it)then I would just back off and let them be. That is just my case and it works for me so far and I have a super mellow, friendly guy.