See my feedback in Red bold. Once I have pics of the cham that will help me further so I can see what is going on with him. Let me know what questions you have.
Your Chameleon - The species, sex, and age of your chameleon. How long has it been in your care? He's 1.5 years old. I've had him since he was 2 or so weeks old.
Handling - How often do you handle your chameleon? I handle him everyday. In the morning and in the afternoon. He gets eye drops twice a day.
Feeding - What are you feeding your cham? What amount? What is the schedule? How are you gut-loading your feeders? He used to eat crickets but he stopped eating them several months ago. He gets superworms, dubai roaches, mealworms and wax worms. I give him horn worms every once in a while. He eats daily and in the afternoon. I rotate his bugs so he doesnt get the same ones everyday. His bugs are gut loaded with apples, kale, collards, turnip greens, and butternut squash.
So at his age he should not be eating daily. With Veileds they will become very obese very quickly after they reach maturity at a year old. You want to feed him 3-5 feeders every other day to every two days depending on his current weight.
Supplements - What brand and type of calcium and vitamin products are you dusting your feeders with and what is the schedule? Repti-calcium without d3 given daily. Repti- calcium with d3 given every 2 weeks. Bee pollen powder used on feeders every once in a while.
You will want to pull him off the calcium with D3 and put him on a multivitamin with D3 and A such as repashy calcium plus LOD. They need the vitamin A in it for eye health. You will use this supplement in place of the calcium with D3 at 2 feedings a month say the 1st and the 15th.
Watering - What kind of watering technique do you use? How often and how long to you mist? Do you see your chameleon drinking? I have an automatic mister that goes off every 4 hours during the day for 2 minutes each time. I do not see him drinking water. I always offer him water via a syringe and he usually drinks from it daily.
So I am guessing you do not have a mistking that you can program for specific misting sessions. This will make it a bit harder because it is better to mist in the morning right after lights come on and then in the evening. You would do longer misting sessions of anywhere from 2-5 minutes depending on your ambient humidity. Most Veileds take a bit to start drinking but not only that a longer misting session allows them to fully clean their eye turrets. The fact that he is drinking from a syringe actually shows that he is overly eager and needs a dripper added to his cage for daytime. You can use something as simple as a plastic solo cup with tiny pin holes in the bottom and set this on the cage screen over plants then add ice cubes for a slower drip. This will provide a consistent dripping which will get his attention.
Fecal Description - Briefly note colors and consistency from recent droppings. Has this chameleon ever been tested for parasites? He used to poop every day when he was younger. Now he poops once or twice a month. When he does poop it's usually a good bit and a dark brown color and it's soft. Not runny at all. He hasn't been tested for parasites but his first vet has given him a wormer before.
So once or twice a month when you are feeding him every day is a big red flag. An adult on average on reduced feeding will pass fecal every 4-7 days. IF they are not this commonly can be linked to dehydration.
History - Any previous information about your cham that might be useful to others when trying to help you. He's been to several vets regarding the same issue. As of yet, no one seems to know what's wrong with him. His blood work came back showing no signs of infection. His liver level was a little elevated. His current vet has me giving him an inflammatory medication and a liver medication orally once a day. He also gets an inflammatory eye drop in both eyes twice a day. I had to take a break on the oral meds because he quit eating. He was eating fine before we started the oral meds.
Once I see pics of his current condition I will be able to access more... The short misting sessions, lack of water during the day, and lack of multivitamin with vitamin A can all impact eye issues.
Cage Info:
Cage Type - Describe your cage (Glass, Screen, Combo?) What are the dimensions? It's a dragon strand hybrid enclosure. It's screen with a pvc back. It's 4'x4' if I'm not mistaken.
Lighting - What brand, model, and types of lighting are you using? What is your daily lighting schedule? I use a reptisun t5 5.0 uvb bulb. He has a regular 75 watt fluorescent light bulb for basking. I recently bought an arcadia jungle dawn 51 watt for his plants. His lights are on a timer from 7am to 7pm.
When was the reptisun bulb replaced? What is the total distance from where it sits on the screen top of the cage to the branches below it?
Temperature - What temp range have you created (cage floor to basking spot)? Very bottom of cage is probably close to 70 or so. He never goes to the bottom of his cage. Middle of cage is in the mid 70's. Basking spot is around 86. Lowest overnight temp? 68 How do you measure these temps? Thermometer in the room and in the cage.
If you can get your night time temps lower 60's he will do much better they really need a cool down at night.
Humidity - What are your humidity levels? In the 50-60's usually. Sometimes it might be in the 40's during the day. How are you creating and maintaining these levels? Automatic mister. What do you use to measure humidity? Thermometer with hygrometer in the room and in his cage.
So Veileds are good with anything between 30-50% daytime, the higher it gets during the day when it is hotter they can start to struggle a bit more. You may see signs of gaping as well which is commonly linked to the humidity sitting too high.
Plants - Are you using live plants? If so, what kind? Yes. I have an umbrella plant and a hisbiscus plant in his enclosure.
All of the fake plants/vines should be removed. These are high risk for him trying to eat them. They can suffer an impaction that without surgery can kill them. Pulling all the nets out would be best. Replacing with real branches. You can get these from outside as long as they are not from Cedar or Pine trees. They really need a hard surface to grip and the nets just do not provide this. Chams have had nails get stuck in these as well and lost their nails. See my cage set ups... one is a Dragon strand atrium. https://www.chameleonforums.com/media/albums/my-enclosures.6672/
Placement - Where is your cage located? Is it near any fans, air vents, or high traffic areas? It's in a back bedroom. It's not in a high traffic area. It's not near any fans or air vents. At what height is the top of the cage relative to your room floor? It's sitting on a plastic table that has a drain rigged up through up. His cage is pretty high up.
Location - Where are you geographically located? I'm located in South Carolina.
Current Problem - The current problem you are concerned about. Getting his eye issues resolved. He also seems to have issues with depth when catching his food.