Eye Black/Kidney Failure/Elevated Uric Acid

M21

Member
I decided to write this post so that hopefully it will give some insight to other members. My Ambilobe Panther Chameleon Yoda is 1.5 years old. Several weeks ago, I noticed he was starting to show discomfort in his left eye. He started closing it a lot. Several days later I noticed it was almost completely black. You couldn't really see the Iris, and he was keeping it closed almost all the time. I decided to take him to the vet to get it checked out. Within days of taking him to the vet, he started dangling his limbs and became lethargic. I will explain more on that later.

Before I continue, I'll list information on his setup including feeders and supplements. I will try to post pictures later of his encloser as well. He is in a relatively large screen encloser. I use a tube fluorescent Reptisun 5.0 T8 and change it every six months. I use a 50W plant grow light and was using a ZooMed Ultra Sun T8 which was also fluorescent. I thought his eye problem could potentially be photo-kerato-conjuctivitis, so I stopped using the ZooMed Ultra Sun immediately. I have multiple vines, a schefflera and pothos in his encloser. I also have a long piece of driftwood. I mist his cage at least twice daily and use a dripper that drips onto the leaves into a Tupperware with a natural sponge. I also use a humidifier to keep up humidity. I typically feed him, hornworms, silkworms, superworms, banana roaches, gutloaded crickets and butterworms. I dust with repcal calcium every feeding. I use reptivite multivitamin with D3 twice a month. I typically dust with repcal calcium with D3 once on the off weeks I'm not using the multi-vitamin. I clean any water that lands on the bottom of the plastic lined encloser and not in the Tupperware daily.

Hopefully that gives everyone some insight to his setup/care. Luckily the vet I took him to is an exotic animal specialist in the Indianapolis area. I told her about his care and setup. She confirmed that my husbandry, supplements and care were all correct. She examined Yoda's eye and luckily found no permanent damage. She suspected that somehow he had poked it causing discomfort and possibly infection. She prescribed Flurbiprofen Sodium Opthalmic Solution and Ofloxacin Opthalmic Solution. She advised me to place drops in his left eye twice daily and wait five minutes in between for eight days. I started the eye treatment and noticed the following day the other negative symptoms (dangling arms/lethargy). I was hoping this was due to the stress from the vet. I called the vet, and she advised me to bring Yoda back in.

She decided to do blood-work due to the new symptoms. She discovered that his uric acid levels were high. She told me it's akin to gout in humans. It is a bad prognosis because that typically means there is a problem with the kidneys and that is hard to treat in chameleons. She ran IV fluids as he was slightly dehydrated as well. She told me she was going to consult with her mentor and come up with the best treatment options. She called me over the weekend and told me she would like to start treating him with Allopurinol orally twice daily along with antibiotics (Ceftazidime) via injection every 72 hours. She believed there was internal bacterial infection as well especially after analyzing his saliva with blood work. She gave me the option to hospitalize him or administer all the meds myself at home. I told her I would rather do it on my own to reduce the stress levels. Also, I would have had to bring in my entire setup with feeders because they did not have that setup at the clinic. She also informed me that when dealing with potential kidney failure, the prognosis is not good and was unsure if the meds would work. She confirmed again that my setup was correct, nothing should be changed, and unfortunately they are unsure of the exact causes of the kidney failure and elevated uric acid levels. She also informed me I should stick to soft-bodied feeders with high water content and not dust with any supplements during his treatment. She advised me to give him warm baths twice daily for a minimum of ten minutes each time as well during his treatment. She said that chameleons are able to absorb small amounts of water through their skin and that it can help with hydration.

The following day Yoda took a major turn for the worse. He was black,stiff and cold. I was certain he would not survive another day. As much as I hated doing it, I decided to go ahead and continue with the treatment. To my surprise, he was still alive the following day. He started drinking as well. Besides offering him water through misting and the dripper, I have started to hold the mister right in front of him and let it drip slowly. He has been drinking that way for two weeks. He drank a considerable amount of water directly from the mister. I do that at least three times a day sometimes over a 20 minute timeframe. To my amazement, he shot his tongue out and ate three silkworms as well. I was planning on force feeding him (vet recommended) if he didn't eat that following day. It had been at least a week since I saw him eat anything. I continued with his two warm baths and oral med treatment. He also had a bowel movement today and the day before yesterday while letting him soak in his bath. It has now been five days since I took him to the vet last. I finished his eye treatment the day before yesterday. It has shown great improvement almost to the point of being back to normal. Yoda is showing signs of improvement with regard to everything. He had become very lethargic and shaky (almost unable to move). He was also keeping both eyes closed off and on the day after the last visit. The last two days he has been much more active. His color has returned to normal. He is not dangling his legs and the shakiness has greatly subsided. Honestly I didn't have much hope for the little guy, but I'm starting to have some optimism that he might pull through. I am going to continue his treatment which should last approximately 2-3 weeks until the meds run out. I am communicating with my vet about his progress and will most likely have blood work done again at the end of his treatment especially if he is continuing to improve.

I wasn't very optimistic about his recovery initially. Chameleons can hide symptoms well until it's too late. I have spent over 400 dollars on his treatment so far and hospitalizing him would have ran me 600-1000 all together. I want him to have the best care, but sometimes it's hard to spend that kind of money especially with a very uncertain long term prognosis. Luckily my job allows me to administer the vets recommended treatment myself and in an environment he's used to, hopefully lowering his stress levels.

I hope that this information is helpful to others out there that may experience similar symptoms with their chameleons. I will try to update his condition throughout. I am very thankful to the Avian & Exotic Animal Clinic in Indianapolis and Dr. Shaw along with her expertise. Because of it, I'm starting to have hope that Yoda will pull through!


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I recently had to put down my rescue Veiled that was suffering from gout and kidney issues, so I'm glad to see Yoda is turning around. He's a handsome little guy. When you were hand misting before all the health issues, how long did you mist for?
 
He is a fighter and looks pretty darn good from the pictures! The only thing I want to comment on is the soaking of your chameleon in the baths. This seems to be the norm with alot of vets out there that chameleons can absorb water through their skin or their cloaca. There is a vet name Dr. Douglas Mader and he is world known, especially with reptiles..Travels all over doing speeches. Writes the books that the vets refer to. My vet even said "he is in a class all by himself". Anyways, I was reading an article he wrote about soaking in water and he claims it is a total misconception and there is no evidence or proof that chameleon's can absorb water through their skin. I am just putting this out there. Yes, your chameleon is doing better, but is it because of the baths?...maybe not. I am just saying this as an option for you especially if your chameleon does not seem to favor this procedure. It is totally up to you, but I just wanted to point this out. Good luck with him!
 
I recently had to put down my rescue Veiled that was suffering from gout and kidney issues, so I'm glad to see Yoda is turning around. He's a handsome little guy. When you were hand misting before all the health issues, how long did you mist for?
I would typically mist for five to ten minutes. I would watch him as well to see if he was going to drink. Anytime I saw him immediately start drinking I would mist until he was finished to ensure enough water stayed on the leaves. I did that two or three times daily with his dripper dripping through multiple leaves throughout the day.
 
He is a fighter and looks pretty darn good from the pictures! The only thing I want to comment on is the soaking of your chameleon in the baths. This seems to be the norm with alot of vets out there that chameleons can absorb water through their skin or their cloaca. There is a vet name Dr. Douglas Mader and he is world known, especially with reptiles..Travels all over doing speeches. Writes the books that the vets refer to. My vet even said "he is in a class all by himself". Anyways, I was reading an article he wrote about soaking in water and he claims it is a total misconception and there is no evidence or proof that chameleon's can absorb water through their skin. I am just putting this out there. Yes, your chameleon is doing better, but is it because of the baths?...maybe not. I am just saying this as an option for you especially if your chameleon does not seem to favor this procedure. It is totally up to you, but I just wanted to point this out. Good luck with him!

Okay thank you for the information. I will try to research it more as well. Honestly the bath does not appear to be high stress for him. As a matter of fact, he seems better especially in the mornings after the warm bath. I've noticed that since starting his treatment he's not always under his basking light in the morning like normal. The warm water seems to get him going. I place him under the basking light after the bath and it's up to him whether he stays there or not. I notice his color is much better after the morning bath as well. He also tends to drink more after the bath and has had two bowel movements while in the bath (something I was becoming concerned about because it had been at least 1.5 weeks since his last).

I use a larger plastic container and don't fill the water so high that he can't easily stand above it. I monitor him throughout. I know it's impossible to tell for sure, but the process doesn't appear to put a lot of stress on him from his behavior. I know forcing his medication orally stresses him but is necessary unfortunately. I could easily see that he was stressed every-time I took him to the vet by his behavior as well. Even if he is unable to absorb any water, it still appears that letting him soak in the warm water is having more positive results, so I will continue it for the time being.
 
So unfortunately Yoda seems slightly worse today. He has been slow moving and shutting his eyes or at least left eye at times. I fear that he is dehydrated. I didn't see him drink water yesterday. I spent extra time today trying to get him to drink. The good news is that he finally did about 20 minutes ago. Patience is key. I misted his encloser four or five times today and had the dripper dripping on the leaves right next to the basking light where he was resting. I held the mister right in front of him and let a couple drops drip on his nose. I waited at least five minutes while doing this and had done it earlier in the day. Luckily he finally started drinking veraciously. I have found that patience with him is extremely important when trying to get him to drink ever since he became ill. I'm still afraid that no matter how much water he drinks, his kidney issues aren't allowing him to utilize it the way they should. I hate this situation, and I hate having to force his meds. This is becoming very saddening. I'm still fearful that even if he shows progress while on the meds, it's only a band-aid and the end result will be the same.

I had another Panther Chameleon before him that lived about four years. I took him to the Purdue Clinic when he started to become ill immediately. They thought there could have been issues brought on by the fact that I used Herptivite containing beta-carotene instead of Reptivite which has vitamin A (I'm sure most are aware of the discussion on whether or not beta-carotene can be converted into vitamin A). I have read that too much vitamin A can be hazardous as well which is why I used the Herptivite with my previous chameleon. Anyways, the vets at Purdue told me the only thing they would have done differently from my setup/care was provide Reptivite as well, so I did (obviously not together) with this chameleon.

It is very saddening and frustrating that Yoda is having these issues at only 1.5 years. Honestly I'm not sure that I can deal with this again. I have researched and researched and tried to care for both of them by the book. If Yoda doesn't pull through this, he may be the last panther I get. I'm sure outsiders probably think I'm crazy for how hard it is for me to watch these little guys struggle, but I'm sure some of the members on here can relate. I probably share a closer bond with my chameleons than our two boxers I inherited when I married my wife (don't tell her that).

I'm going to post a couple pictures of Yoda that I just took today.

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So unfortunately Yoda seems slightly worse today. He has been slow moving and shutting his eyes or at least left eye at times. I fear that he is dehydrated. I didn't see him drink water yesterday. I spent extra time today trying to get him to drink. The good news is that he finally did about 20 minutes ago. Patience is key. I misted his encloser four or five times today and had the dripper dripping on the leaves right next to the basking light where he was resting. I held the mister right in front of him and let a couple drops drip on his nose. I waited at least five minutes while doing this and had done it earlier in the day. Luckily he finally started drinking veraciously. I have found that patience with him is extremely important when trying to get him to drink ever since he became ill. I'm still afraid that no matter how much water he drinks, his kidney issues aren't allowing him to utilize it the way they should. I hate this situation, and I hate having to force his meds. This is becoming very saddening. I'm still fearful that even if he shows progress while on the meds, it's only a band-aid and the end result will be the same.

I had another Panther Chameleon before him that lived about four years. I took him to the Purdue Clinic when he started to become ill immediately. They thought there could have been issues brought on by the fact that I used Herptivite containing beta-carotene instead of Reptivite which has vitamin A (I'm sure most are aware of the discussion on whether or not beta-carotene can be converted into vitamin A). I have read that too much vitamin A can be hazardous as well which is why I used the Herptivite with my previous chameleon. Anyways, the vets at Purdue told me the only thing they would have done differently from my setup/care was provide Reptivite as well, so I did (obviously not together) with this chameleon.

It is very saddening and frustrating that Yoda is having these issues at only 1.5 years. Honestly I'm not sure that I can deal with this again. I have researched and researched and tried to care for both of them by the book. If Yoda doesn't pull through this, he may be the last panther I get. I'm sure outsiders probably think I'm crazy for how hard it is for me to watch these little guys struggle, but I'm sure some of the members on here can relate. I probably share a closer bond with my chameleons than our two boxers I inherited when I married my wife (don't tell her that).

I'm going to post a couple pictures of Yoda that I just took today.

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Unfortunately from what I've read in this site, chameleons don't really do well with a lot of medication. If he's already having issues with his kidneys, it's generally just a matter of time. I don't think you can really heal them as much as slow their decline.

From my discussions with my own vet about Allopurinol, it can take a while to really work, so I would continue per your vet's instructions and keep up the good work keeping him hydrated.

As for your bond with the little guy, it can be very hard to explain it to non-reptile people, but you're definitely among similar company here. I'm still having a hard time getting over the decision I had to make to put my rescue guy down, and I only had him a few months. I know, as do many others here, the emotional stress it puts on you, always monitoring and worrying about every little thing, hoping and trying every option to try and get them better.

It doesn't sound like Yoda is done fighting yet, so keep giving him a chance. We're all hoping he pulls through.
 
So unfortunately Yoda seems slightly worse today. He has been slow moving and shutting his eyes or at least left eye at times. I fear that he is dehydrated. I didn't see him drink water yesterday. I spent extra time today trying to get him to drink. The good news is that he finally did about 20 minutes ago. Patience is key. I misted his encloser four or five times today and had the dripper dripping on the leaves right next to the basking light where he was resting. I held the mister right in front of him and let a couple drops drip on his nose. I waited at least five minutes while doing this and had done it earlier in the day. Luckily he finally started drinking veraciously. I have found that patience with him is extremely important when trying to get him to drink ever since he became ill. I'm still afraid that no matter how much water he drinks, his kidney issues aren't allowing him to utilize it the way they should. I hate this situation, and I hate having to force his meds. This is becoming very saddening. I'm still fearful that even if he shows progress while on the meds, it's only a band-aid and the end result will be the same.

I had another Panther Chameleon before him that lived about four years. I took him to the Purdue Clinic when he started to become ill immediately. They thought there could have been issues brought on by the fact that I used Herptivite containing beta-carotene instead of Reptivite which has vitamin A (I'm sure most are aware of the discussion on whether or not beta-carotene can be converted into vitamin A). I have read that too much vitamin A can be hazardous as well which is why I used the Herptivite with my previous chameleon. Anyways, the vets at Purdue told me the only thing they would have done differently from my setup/care was provide Reptivite as well, so I did (obviously not together) with this chameleon.

It is very saddening and frustrating that Yoda is having these issues at only 1.5 years. Honestly I'm not sure that I can deal with this again. I have researched and researched and tried to care for both of them by the book. If Yoda doesn't pull through this, he may be the last panther I get. I'm sure outsiders probably think I'm crazy for how hard it is for me to watch these little guys struggle, but I'm sure some of the members on here can relate. I probably share a closer bond with my chameleons than our two boxers I inherited when I married my wife (don't tell her that).

I'm going to post a couple pictures of Yoda that I just took today.

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I am sorry thatYoda is not doing as well as before. I completely understand how you feel as I have the same attachment to my Chams. Letting go it very heartbreaking and I struggle with the decision to keep Chams. But I can't imagine life without them. Hang in there, we will just hope for the best for Yoda and you.
 
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Okay thank you for the information. I will try to research it more as well. Honestly the bath does not appear to be high stress for him. As a matter of fact, he seems better especially in the mornings after the warm bath. I've noticed that since starting his treatment he's not always under his basking light in the morning like normal. The warm water seems to get him going. I place him under the basking light after the bath and it's up to him whether he stays there or not. I notice his color is much better after the morning bath as well. He also tends to drink more after the bath and has had two bowel movements while in the bath (something I was becoming concerned about because it had been at least 1.5 weeks since his last).

I use a larger plastic container and don't fill the water so high that he can't easily stand above it. I monitor him throughout. I know it's impossible to tell for sure, but the process doesn't appear to put a lot of stress on him from his behavior. I know forcing his medication orally stresses him but is necessary unfortunately. I could easily see that he was stressed every-time I took him to the vet by his behavior as well. Even if he is unable to absorb any water, it still appears that letting him soak in the warm water is having more positive results, so I will continue it for the time being.

I suspect he seems to be looking better after a warm bath is simply because he has increased his body temperature in the bath so is more active. Which is also why he isn't so interested in basking in the morning--he doesn't need to because he is already warm.

Something to keep in mind,defecation is a stress response. Stress might have been the reason he defecated twice in the bath. Something to think about.
 
I suspect he seems to be looking better after a warm bath is simply because he has increased his body temperature in the bath so is more active. Which is also why he isn't so interested in basking in the morning--he doesn't need to because he is already warm.

Something to keep in mind,defecation is a stress response. Stress might have been the reason he defecated twice in the bath. Something to think about.

I am aware that defecation can be a stress response, however I've never see him go as long as he did without defecating. He is active, eyes wide open and moving around this morning. It's really a day to day process at this point. I don't know if the treatment I'm giving him is absolutely perfect. I wish I did. I feel like all I can do at this point is continue treating him per the vets recommendations. I honestly didn't think he would be alive after he took his really bad turn initially before starting treatment. I may cut back to one warm bath a day and then none if he has several days where he is looking like he is right now. I appreciate everyone's feedback including yours. I hate doing anything that causes stress especially orally forcing meds. It's even harder when I receive somewhat conflicting information from the treatment my vet has told me to follow.
 
I am aware that defecation can be a stress response, however I've never see him go as long as he did without defecating. He is active, eyes wide open and moving around this morning. It's really a day to day process at this point. I don't know if the treatment I'm giving him is absolutely perfect. I wish I did. I feel like all I can do at this point is continue treating him per the vets recommendations. I honestly didn't think he would be alive after he took his really bad turn initially before starting treatment. I may cut back to one warm bath a day and then none if he has several days where he is looking like he is right now. I appreciate everyone's feedback including yours. I hate doing anything that causes stress especially orally forcing meds. It's even harder when I receive somewhat conflicting information from the treatment my vet has told me to follow.

Why don't you mist him with warm water rather than put him in a bath? You'll do the same thing--get his skin wet but without all the stress.

He might not be defecating because he isn't eating.
 
Luckily the vet I took him to is an exotic animal specialist in the Indianapolis area.

I am very thankful to the Avian & Exotic Animal Clinic in Indianapolis and Dr. Shaw along with her expertise.

That's good to know, because I live in the Indianapolis area. I used to live over near Broad Ripple but recently moved out of Indy and into Fishers like 10 minutes away. I've did a bit of looking around for an exotic reptiles vet in the area, and luckily I've never needed one yet. If I WAS to need one though, I didn't know which one I would pick, based on the short list that I compiled. Good to know that there is a good one in the area that helped you; I will keep that in mind.

Where exactly do you live at @M21 ? Are you living in Indianapolis or are you just nearby?
 
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Why don't you mist him with warm water rather than put him in a bath? You'll do the same thing--get his skin wet but without all the stress.

He might not be defecating because he isn't eating.

Why don't you mist him with warm water rather than put him in a bath? You'll do the same thing--get his skin wet but without all the stress.

He might not be defecating because he isn't eating.

I was doing that before starting the bath treatment. He seems to hate being misted. He always tries to take off. I only started the bath because my vet told me to. I had never soaked any of my chameleons prior to that only misted.

He had eaten several times in that time span where I hadn't seen him defecate. I actually saw him eat two super-worms and three silkworms.
 
That's good to know, because I live in the Indianapolis area. I used to live over near Broad Ripple but recently moved out of Indy and into Fishers like 10 minutes away. I've did a bit of looking around for an exotic reptiles vet in the area, and luckily I've never needed one yet. If I WAS to need one though, I didn't know which one I would pick, based on the short list that I compiled. Good to know that there is a good one in the area that helped you; I will keep that in mind.

Where exactly do you live at @M21 ? Are you living in Indianapolis or are you just nearby?

I sent you a PM.
 
I was doing that before starting the bath treatment. He seems to hate being misted. He always tries to take off. I only started the bath because my vet told me to. I had never soaked any of my chameleons prior to that only misted.

He had eaten several times in that time span where I hadn't seen him defecate. I actually saw him eat two super-worms and three silkworms.

I decided to only mist him today (he went running away like usual) with warm water as opposed to letting him soak (I keep the mister at a good distance with a fine mist and try to avoid his eyes as much as possible to not startle him). I'm torn between following my vet on this and following other's advice including yours as well as my own past care with regard to this. Today he was not shaking as much and seemed to have good control of his limbs. I can still see plenty of indicators that he is ill however. I'm becoming more concerned about his weight and general appearance. I'm letting hornworms, silkworms and crickets free-range. I also have butterworms in his dish. I'm coming to the decision that I want him to be as comfortable as possible, which is why I just misted him today. Even though it doesn't appear to be stressing him and I already have him out to administer his meds, I don't want to take any chances of potentially stressing him more than I have to. I'm afraid I'm just buying him some time with his treatment, but he's not to the point yet where I'm going to stop giving him the meds and give up.

Again I appreciate your advice, along with the advice from other members. I'm trying my best to provide the meds and care my vet recommended while trying to keep him comfortable and as stress free as possible.
 
Here's an update on Yoda. He's over half way on receiving his treatment and surprisingly still alive. I have completely stopped giving him warm baths and only mist. He still doesn't look very good most of the day and let's his arms dangle. The problem has returned with his eye, so I've started treatment on that again the last two days. He has still been drinking out of the mister about every other day. I've added the Biobubble Reptile Drinking Fountain to his encloser (must be cleaned daily) while still misting along with using a dripper and humidifier.

He has lost weight but is starting to shed and I actually saw him eat three crickets today! I have given up hope on more than one occasion already, but still continued caring for him and giving him his meds. He is definitely a fighter and seeing him eat those crickets today gave me some encouragement!

I am almost out of the pain relieving drops for his eye. That along with the antibiotics was supposed to be given for seven days. I still have a lot of the antibiotic for his eye remaining. His eye was better but got worse again. Does anyone have experience with giving antibiotics for an eye infection longer than seven days? I will probably call my vet tomorrow to ask if I should continue with the eye antibiotics and get a refill for the eye drops for pain. I'm hoping to get a fecal sample to take to the vet asap as well. I still have four antibiotic injections (72 hours in between each injection) left to give out of nine and probably four days of the oral medication to lower his uric acid levels left.
 
Here is a photo of the Biobubble Drinking Fountain. It looks like it could be a nice addition for hydration if used in addition to misting, dripper, humidifier and cleaned daily.
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Here are pictures of Yoda tonight. He looks plump and healthy in these pictures. I just hope his eye heals and he stops dangling his arms. You can see he's starting to shed in one of the pictures.
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