Jared, your husbandry needs a little help.
First, the cage will be of adequate size for just him. As others have stated, you need to keep your male alone for a host of reasons...especially now. The cage needs to be relocated. Putting it on the ground leave the chameleon feeling unsafe. When you walk up to a cham and you're looking down on it, it will be thinking "Okay, I'm done for! I'm gonna get eaten!" Always try to put the cage high enough that the cham can climb to eye level or higher. On top of a desk, work bench, dresser, shelf, these are all better choices.
Second, the cage needs to be more densely planted. More living plants if you can. Any Lowes, Target, Walmart, Home Depot, or OSH will have what you need...schefflera arboricola, pothos, or ficus benjamina. You can layer the cage to provide leaves at every level by using zip ties, flower stands, any reptile vine, twine, or twist ties from the produce section of your local grocery store. With more vegetation at every level in the cage, your cham can hide (feel more safe), drink easier by licking off all the leaves, hunt, and enjoy a higher humidity.
Third, lose the waterfall. It will become filled with bacteria and it doesn't do any good. Chams are not like dogs, they prefer to lick water off leaves.
Fourth, get a fecal. Any poop that you can be sure the new (unhappy) cham dropped, take straight to the vet and ask for a fecal. Shouldn't run you more than $30 and it will tell you if your cham has parasites or not. If so, your vet can prescribe meds to help get your dude back in the saddle.
Fifth, lose the substrate. There is no reason, other than aesthetics, to have a ground cover for an arboreal species. It'll be easier to clean and you won't have to worry about your chams accidentally ingesting anything.
Sixth, we need the information in the above post to help you further. We need to know your temperatures: basking spot temp, mid level temp, and low level temp. Also, a humidity reading would be useful.
Hope this was useful!