To address Desitiny's comment. All panther chameleons, ambilobe, ankaramy, nosy be, ambanja, or whatever it may be, all belong to the same species, Furcifer Pardalis. The only difference is the colouring that they will display. Think of it as the dozens of morphs availabe in leopard geckos. Many breeders advise against breeding locale crosses (NOT species crosses) merely as a way to keep lines pure, similar to thoroughbred horses or dogs. The gecko enthusiast in me would have little apprehension mixing locales, as long as you can keep proper records, outlining the exact mixes of all offspring, and that you care enough and respect anyone who would by from you and tell them the exact genetics.
Defects should only occur after generations of inbreeding, which I highly look down upon.