i took my chams to my parents house for the weekend awhile ago, all i did was throw their entire enclosure into the backseat of my car and strap them in. as long as the stuff in the enclosure cant move you should be fine, just drive easy. I think i stressed about the drive more than they did, their colors looked normal, on the way back they just slept the whole way. But as mentioned above, i wouldnt take them far if they are very young, my chams are juveniles and were healthy before the trip