Okay, the the thing in the bottom right hand corner is her waterfall. She loves that thing. Last night I dangled crickets in front of her good eye and she doesn't want to eat. But she's still moving around. The bottom of her tank is paper toweling. She seems to be going to the bathroom just fine, yet she's so thin. Her eye is HUGE today. I'm going to turn up the shower and raise the humidity in the bathroom and sit her in there. She hates showers, so maybe this would be the next best thing. And for the questions:
1. Cage type: What size and type of cage (screen, glass, etc.)? Screen. I seen someone else on this forum with the same exact cage.
2. Temperatures: What is the basking temperature? How do you measure the temperature in your setup? What is the temperature in the warmest spot? The coolest spot? At night? During the day? You should measure the temperature of the chameleons' skin or the surface of its current branch to get a more accurate reading. Do you leave any heat on at night? What is the temperature in the room at night? Upper 80's. I have this tricky looking thing I got from a petstore to measure the temp. It seems accurate. The warmest spot is around 95. The coolest spot would be 72. I don't have any heat on at night because we all like it warm in here, lol. Just a towel to keep up humidity.
3. Lighting: What brand is your UVB light? How long have you been using it? How long are your lights on each day? Do you leave any lights on at night? Where are the lights? on top? Brand new Repti sun 10.0. 12 hours on, 12 off. Nothing at night, only a towel covering half the cage to reduse the loss of so much humidity.
4. Humidity: Do you have a humidity gauge? What is the range of relative humidity (RH) from lowest to highest? How long does it take to go from high to low? Do you use a humidifier? Do you live in the north or south (or other)? I live in NY, and I do have a humidity gauge. I usually keep good track of it because I don't want her to have a bad shed.
5. Water: Have you observed your chameleon drinking? How often do you mist? Do you have a dripper? I have a waterfall which I have seen her drink from. She also drinks from the misting bottle when I mist her if she's in the mood.
6. Food: Have you observed your chameleon eating? What is the chameleon's diet? Where do you get your live feeder prey? What are you feeding the feeders? Fresh veggies? Gut load? If you use a commercial gut load what is the brand? If you make your own what are the ingredients?
7. Supplements: What type of supplement(s) do you use? Brand name(s)? How often do you use supplements?
8. Plants & branches: What plants do you have? Are your plants alive or fake? Do the plants provide lots of coverage where the chameleon will feel safe? Can you see your chameleon most of the time or can it hide from your view? I have a sticks and reptile branches in with her. There's also fake ivy looking leaves like in the picture.
9. Chameleon facts: How old is the chameleon? Do you know if it is wild caught or captive born? Did you get the chameleon at a show? Breeder? Petstore. I know nothing of her background.
10. Handling: Do you handle your chameleon? How often and how long? What is its reaction to you? Is the cage in a quiet part of the house or is it in a busy or noisy area? Any big stereo speakers near the cage? Is your chameleon alone in the cage? Can your chameleon see any other herps or pets from the cage? My beardie is in the other room because I didn't want to upset either one of them. She's currently in my bedroom, which my fiance and I usually stay half the time. I don't take her out because I'm pretty sure she hates it. She only comes out when I clean her tank. She's also housed alone.
11. Veterinarians: Do you have a veterinarian who KNOWS chameleons? My vet for my dogs gave me a number to a reptile vet the other day, so she'll be going there if you guys think she should.
If I'm doing something wrong please help. I'm going to turn on the shower now and keep you all up to date on her stats. I'm also going to call the vet and see what she says.

And I remember someone on this forum saying Senegal Chameleons are always in the worst shape. I guess they were right.