“CUTANEOUS SQUAMOUS CELL CARCINOMA IN A PANTHER CHAMELEON (Furcifer pardalis) AND TREATMENT WITH CARBOPLATIN IMPLANTABLE BEADS
James G. Johnson III, DVM,1* Lisa M. Naples, DVM,2 Caroline Chu, DVM, MS,3 Michael J. Kinsel, DVM, Dipl ACVP,3 Jennifer E. Flower, DVM, MS,1 and William G. Van Bonn, DVM2
1Illinois Zoological and Aquatic Animal Residency Program, Urbana, IL 61802 USA; 2A. Watson Armour III Center for Animal Health, John G. Shedd Aquarium, Chicago IL 60605 USA; 3Zoological Pathology Program, University of Illinois, Maywood, IL 60513 USA
Abstract
A 3-yr-old male panther chameleon (Furcifer pardalis) presented with two bilateral raised and crusted skin lesions on the thorax. These lesions were excised and submitted for histopathology with subsequent diagnoses of carcinoma in situ and squamous cell carcinoma. Despite incomplete excision of the squamous cell carcinoma, both excision sites healed; however, several more lesions with a similar appearance developed along both flanks and the tail. The incompletely excised squamous cell carcinoma was re-excised and a piece of implantable carboplatin bead (Wedgewood Pharmacy, Swedesboro, NJ 08085 USA) was placed in the excision site at 5 mg/kg to evaluate this animal’s tolerance of this therapy. Two of the new lesions were sampled for histopathology and viral polymerase chain reaction (PCR) due to the multifocal nature of the lesions. Histopathology confirmed squamous cell carcinoma in the new location and PCR was negative for both papillomaviruses and herpesviruses. Due to the significant skin loss that would result from attempting complete excision of all lesions, implantable carboplatin beads were placed in each lesion. A maximum carboplatin dosage of 10 mg/kg within a 3-wk period was not exceeded. The animal was monitored for response to therapy and no adverse effects of the carboplatin beads were observed. Tumor excision sites treated with beads healed with no tumor recurrence and lesions notexcisedandtreatedwithbeadsdecreasedinsize. Thisisthefirstreportofcutaneoussquamous cell carcinoma in a panther chameleon, as well as the first description of implantable carboplatin bead use in this species.”…
https://cdn.ymaws.com/www.eazwv.org...D-A14C-A6604318474F/2015 AAZV proceedings.pdf
James G. Johnson III, DVM,1* Lisa M. Naples, DVM,2 Caroline Chu, DVM, MS,3 Michael J. Kinsel, DVM, Dipl ACVP,3 Jennifer E. Flower, DVM, MS,1 and William G. Van Bonn, DVM2
1Illinois Zoological and Aquatic Animal Residency Program, Urbana, IL 61802 USA; 2A. Watson Armour III Center for Animal Health, John G. Shedd Aquarium, Chicago IL 60605 USA; 3Zoological Pathology Program, University of Illinois, Maywood, IL 60513 USA
Abstract
A 3-yr-old male panther chameleon (Furcifer pardalis) presented with two bilateral raised and crusted skin lesions on the thorax. These lesions were excised and submitted for histopathology with subsequent diagnoses of carcinoma in situ and squamous cell carcinoma. Despite incomplete excision of the squamous cell carcinoma, both excision sites healed; however, several more lesions with a similar appearance developed along both flanks and the tail. The incompletely excised squamous cell carcinoma was re-excised and a piece of implantable carboplatin bead (Wedgewood Pharmacy, Swedesboro, NJ 08085 USA) was placed in the excision site at 5 mg/kg to evaluate this animal’s tolerance of this therapy. Two of the new lesions were sampled for histopathology and viral polymerase chain reaction (PCR) due to the multifocal nature of the lesions. Histopathology confirmed squamous cell carcinoma in the new location and PCR was negative for both papillomaviruses and herpesviruses. Due to the significant skin loss that would result from attempting complete excision of all lesions, implantable carboplatin beads were placed in each lesion. A maximum carboplatin dosage of 10 mg/kg within a 3-wk period was not exceeded. The animal was monitored for response to therapy and no adverse effects of the carboplatin beads were observed. Tumor excision sites treated with beads healed with no tumor recurrence and lesions notexcisedandtreatedwithbeadsdecreasedinsize. Thisisthefirstreportofcutaneoussquamous cell carcinoma in a panther chameleon, as well as the first description of implantable carboplatin bead use in this species.”…
https://cdn.ymaws.com/www.eazwv.org...D-A14C-A6604318474F/2015 AAZV proceedings.pdf
