Sorry, I missed this until now....
He may very well have developed vitamin deficiencies.
Unfortunately, the Fluker's orange is not nutritious--please see here for good gutloads
https://www.chameleonforums.com/care/food/
He should also have 2 feedings each month dusted with a multivitamin powder.
A varied diet is also beneficial because different bugs retain different levels of the various vitamins and minerals.
As for the benign tumor beneath his eye, this sounds like it may actually be an infection.
Eye infections are common when a vitamin A deficiency is present.
If this hasn't been diagnosed by a good cham knowledgeable vet, then it would be to your cham's benefit to have him examined.
A vet can give him a safe boost of vitamin A, as well as an antibiotic.
Has he gotten a new UV bulb after the old one turned 6 months old?
If not, he should get a new one.
The UV bulbs still give off plenty of non-UV long after they stop giving off UV.
His new cage, if you furnish it with plenty of foliage, may help him to be a little happier, too.