On contrary...I like the coloring.... and Syn its called Depth of Field, not blur.
I think though you might want to try the shot again with a different white balance, I assume your chameleon is under the normal Basking and UVB combo - which makes pictures hard because of the confusing light spectrum. Turn one of them off, and adjust the white balance to compensate.
However I like your DOF and the ISO seems fine for that shot, but test with the lighting, you might decide to bump it up a tad.
S.F